Rosuvastatin Intermediates Z-8
5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine
CAS: 799842-07-2
Molecular Formula: C16H19BrFN3O2S
Rosuvastatin Intermediates Z-8 - Names and Identifiers
Rosuvastatin Intermediates Z-8 - Physico-chemical Properties
| Molecular Formula | C16H19BrFN3O2S |
| Molar Mass | 416.31 |
| Density | 1.466 |
| Boling Point | 531.2±60.0 °C(Predicted) |
| Flash Point | 275.047°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | -0.77±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.586 |
Rosuvastatin Intermediates Z-8 - Introduction
5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine is an organic compound with a chemical formula of C≡¾ H≡BrFN≡OYS and a relative molecular mass of 430.32g/mol.
Nature:
1. Appearance: white crystalline powder.
2. Solubility: Soluble in organic solvents, such as chloroform, dichloromethane and ethanol.
3. melting point: about 134-135 ℃.
4. Stability: relatively stable at room temperature, but avoid contact with strong oxidants.
Use:
5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine is often used in organic synthesis as an important intermediate. It can be used to synthesize other organic compounds, such as pesticides, pharmaceuticals and functional materials.
Preparation Method:
the preparation method of 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine is relatively complicated, and a commonly used preparation method is as follows:
1.4-fluorobenzaldehyde reacts with pyrimidine -2-amine to generate 4-(4-fluorophenyl) pyrimidine.
2.4-(4-fluorophenyl) pyrimidine is reacted with methyl tert-butyl ketone and propylene iodide to generate 5-(4-methylpropenyl)-4-(4-fluorophenyl) pyrimidine.
3.5-(4-methylpropenyl)-4-(4-fluorophenyl) pyrimidine reacts with chloromethyl to generate 5-(bromomethyl)-4-(4-fluorophenyl) pyrimidine.
4. Finally, 5-(bromomethyl)-4-(4-fluorophenyl) pyrimidine is reacted with methanesulfonyl chloride to give the final product 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isoppropyl-2-[methyl(methylsulfonyl)amino]pyrimidine.
Safety Information:
The following safety precautions are required when using the 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine:
1. Avoid inhaling dust and operate in a well-ventilated place.
2. contact with skin or eyes, should immediately rinse with plenty of water.
3. Store in a cool, dry place, away from fire and oxidants.
4. Waste must be disposed of correctly, referring to local regulations.
Important note: The information provided here is for reference only. In actual application, it must be operated according to the specific situation and follow the safe operation specifications of chemical experiments.
Nature:
1. Appearance: white crystalline powder.
2. Solubility: Soluble in organic solvents, such as chloroform, dichloromethane and ethanol.
3. melting point: about 134-135 ℃.
4. Stability: relatively stable at room temperature, but avoid contact with strong oxidants.
Use:
5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine is often used in organic synthesis as an important intermediate. It can be used to synthesize other organic compounds, such as pesticides, pharmaceuticals and functional materials.
Preparation Method:
the preparation method of 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine is relatively complicated, and a commonly used preparation method is as follows:
1.4-fluorobenzaldehyde reacts with pyrimidine -2-amine to generate 4-(4-fluorophenyl) pyrimidine.
2.4-(4-fluorophenyl) pyrimidine is reacted with methyl tert-butyl ketone and propylene iodide to generate 5-(4-methylpropenyl)-4-(4-fluorophenyl) pyrimidine.
3.5-(4-methylpropenyl)-4-(4-fluorophenyl) pyrimidine reacts with chloromethyl to generate 5-(bromomethyl)-4-(4-fluorophenyl) pyrimidine.
4. Finally, 5-(bromomethyl)-4-(4-fluorophenyl) pyrimidine is reacted with methanesulfonyl chloride to give the final product 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isoppropyl-2-[methyl(methylsulfonyl)amino]pyrimidine.
Safety Information:
The following safety precautions are required when using the 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine:
1. Avoid inhaling dust and operate in a well-ventilated place.
2. contact with skin or eyes, should immediately rinse with plenty of water.
3. Store in a cool, dry place, away from fire and oxidants.
4. Waste must be disposed of correctly, referring to local regulations.
Important note: The information provided here is for reference only. In actual application, it must be operated according to the specific situation and follow the safe operation specifications of chemical experiments.
Last Update：2024-04-09 21:00:56
Supplier List
Spot supply
Product Name: Rosuvastatin Impurity 103 Visit Supplier Webpage Request for quotationCAS: 799842-07-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine Visit Supplier Webpage Request for quotationCAS: 799842-07-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Rosuvastatin Impurity 103 Visit Supplier Webpage Request for quotationCAS: 799842-07-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine Visit Supplier Webpage Request for quotationCAS: 799842-07-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History